Marvel's Spider-Man Eternal (SPE), a main expansion for Magic: The Gathering, officially launched on September 26, 2025. This 26-card set draws upon the Marvel's Spider-Man universe, a setting within the MTG multiverse previously explored in Eternal Masters.

The set's gameplay introduces several key mechanics. Superpower is an activated ability on creatures, usable once for +1/+1 counters and other effects, discounted if activated the turn it enters. Teamwork is an optional additional cost for instants and sorceries, tapping creatures for an additional or enhanced effect. Project is an enchantment subtype with triggered abilities that add project counters for incremental and final rewards. The keyword action Conspire involves a creature drawing and discarding a card, putting a +1/+1 counter if a nonland card is discarded. Additionally, the set features the condition Worthy, for legendary red and/or white creatures that are not Enemies, and Harness, an activated ability on The Mind Stone to enable its powerful ∞ ability. These mechanics, alongside transforming Modal Double-Faced Cards, foster diverse strategies, ranging from aggressive creature-based archetypes, particularly in Red and White, to more methodical enchantment-driven or control-oriented play in Blue and Black. The complete card list from this set can be reviewed in the gallery above.